In this study done in Ibaraki, Japan, keratoconus and cornea researchers wanted to see whether three-dimensional (3D) corneal and anterior segment optical coherence tomography (CAS-OCT) or a rotating Scheimpflug camera combined with a Placido topography system (Scheimpflug camera with topography) was better to study the cornea. They wanted to see how it would be best to detect the signs of early keratoconus disease. Their goal was to asses if normal eyes and forme fruste keratoconus could be separated based on that criteria. They found out that both systems worked equally good. Our own Los Angeles Keratoconus Expert feels an early cornea topography works equally good in the hands of an experienced keratoconus expert.
RESULTS: CLEK Study subjects had a mean age at baseline of 39.3+/-10.9 years. At study entry, 65% of the patients wore rigid contact lenses, and 14% reported a family history of the disease. Subjects exhibited a 7-year decrease in high- (2.03 letters) and low- (4.06 letters) contrast, best-corrected visual acuity, with 19% demonstrating decreases of 10 or more letters in high-contrast, best-corrected acuity and 31% of subjects demonstrating decreases of 10 or more letters in low-contrast, best-corrected acuity in at least one eye. Subjects exhibited an average 8-year increase in corneal curvature of 1.60D in the flat corneal meridian, with 24% demonstrating increases of 3.00D or more. The 8-year incidence of corneal scarring was 20%, with younger age, corneal staining, steeper baseline corneal curvature, contact lens wear, and poorer low-contrast visual acuity predictive of corneal scarring. Data from the National Eye Institute Visual Function Questionnaire suggest that the effect of keratoconus on vision-specific quality of life is disproportionate to its low prevalence and clinical severity.