Epi on or Epi off Crosslinking- that is the question

Keratoconus progression can be halted by corneal collagen cross linking has been established. We thank all our patients who believed and participated in the trials. Now the hot question is which is better- to remove epithelium or to leave it alone.The debate has recently become intense. Various specialists have filed trade marks, patents or invested in a particular technology. Sometimes their opinions seem biased. So where do we turn to if we want to know the true answer?

Riboflavin cornea cross linking
How about the FDA? They are experts at looking at the data and known for they unbiased opinion. They have the interest of American patients in mind.

They analyzed lot of safety data. Here is what they have approved in USA 

Epi off cornea cross linking 

So that means so far Epi off is better than epi on or it’s variations like c3R

The epithelium interferes in the seepage of riboflavin i the cornea. It also hinders the uniform transmission of uvA . Therefore it a good idea to remove it

Some may disagree and say FDA process is tedious and hence Epi on is still stuck somewhere. We can than turn to peer reviewed journals. No published study has ever shown that Epi on crosslinking is better than Epi off.

Multiple studies have shown that Epi on Cross linking is the current Gold Stsndard.

So we rest our case

Epi off cross linking is the procedure Keratoconus specialists recommend 

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